The first comprehensive single-authored textbook on genome-scale models and the bottom-up approach to systems biology. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Found inside – Page 1272Theoretical models of the evolution of reproductive systems often make specific predictions of both expected character associations ... by recent disagreements about this concept between workers in phylogenetics and comparative biology , on one hand , and those ... By including the environmental context in our definition we further identify that specific traits do not usually have intrinsic ecological value . Found insideThe definition of what Systems Biology is was discussed in most interviews. ... Different types of system definitions can be distinguished when seeking ... In particular the work focuses on the engineering of biological systems and network modeling. Found insideIt highlights simple, recurring circuit elements that make up the regulation of cells and tissues. Rigorously classroom-tested, this edition includes new chapters on exciting advances made in the last decade. This book constitutes the thoroughly refereed post-proceedings of two joint RECOMB 2006 satellite events: the Second Annual Workshop on Systems Biology, RSB 2006, and the First Biennial Workshop on Computational Proteomics, RCP 2006, held ... The book begins from the essentials of singular systems theory and bifurcations before tackling the use of various forms of control in singular biological systems using examples including predator-prey relationships and viral vaccination ... Found inside – Page 249Definitions and Perspectives Lilia Alberghina, Hans V. Westerhoff ... in an iterative fashion, which is characteristic of the systems biology approach. Found inside – Page 199We define the function βv between the set R+ and the set [[0,p]] that maps each positive real number v ∈ R+ ... Definition 5 (Abstract Transition System). Found insideThis volume aims to provide a timely view of the state-of-the-art in systems biology. Given the scope of its analysis, this book might interest both philosophically inclined biologists and philosophers of biology, as well as, more generally, readers who think critically about the methodology of science. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Found inside – Page 56One definition of an autonomous self - replicating system that operates at the molecular level is a biological ... We could define a biological system in this way , but it would have a bit of looseness to it ; we would have to patch up the definition if ... Found insideThus the book serves as a must-have guide for undergraduates and graduate students interested in Biochemical Engineering and Microbial Biotechnology Systems biology is a term used to describe a number of trends in bioscience research and a movement that draws on those trends. This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology. First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the ... As a volume of the highly successful Methods in Molecular BiologyTM series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Found inside – Page 80Definition 4 (Boolean Activationn Functions). The Boolean activation functions xk → {0,1}, 1 ≤ k ≤ n, of an influence system +, xk − : {0,1} M are xk + ... Found inside – Page 74It is structured into several lists that define different properties of the model. The most important lists that are frequently used are the definition of ... Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. Found inside – Page 93Definition 4. A Component-level Type Graph (CTG) of a biochemical system comprises a pair (CV,CE), where CV is a set of vertex (component) types, ... In Dynamic Models in Biology, the first text on dynamic models specifically written for undergraduate students in the biological sciences, ecologist Stephen Ellner and mathematician John Guckenheimer teach students how to understand, build, ... Analyzes approaches to the study of complexity in the physical, biological, and social sciences. This book constitutes the refereed proceedings of the 14th International Conference on Computational Methods in Systems Biology, CMSB 2016, held in Cambridge, UK, in September 2016. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, ... A valuable reference for researchers, this text offers a sound starting point for scientists entering this fascinating and rapidly developing field. Globalization, Biosecurity, and the Future of Life Sciences examines current trends and future objectives of research in public health, life sciences, and biomedical science that contain applications relevant to developments in biological ... Found insideThis book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. The Encyclopedia of Systems Biology is conceived as a comprehensive reference work covering all aspects of systems biology, in particular the investigation of living matter involving a tight coupling of biological experimentation, ... Second, SB's methodological failure has substantive philosophical consequences---explained in this work---relevant to the debate concerning the scientific status of biology, the fate of the unity of science project, and the agenda of ... The theme of this book is the self-generation of information by the self-modification of systems. Found inside – Page 207531-537. (SAE PAPER 860969) The Life Sciences Research Facility dedicated laboratory is currently undergoing system definition within the NASA Space Station program. Attention is presently given to the Humam Research Project portion of ... Found inside – Page 25BIOLOGICAL CONTROL OF PLANT PATHOGENS: DEFINITIONS Ralph Baker "If you wish to converse with me," Voltaire said, "define your terms. List of figures. Preface to the 1992 edition. Preface. The general setting. A formal framework. lustrations. Schemata. The optimal allocation of trials. Reproductive plans and genetic operators. The robustness of genetic plans. Found inside – Page 69Definition 4. ... To describe the dynamics of such an automaton formally, we use the notion of a transition system. Definition 5. Found inside – Page 285The definitions above refer to Bio-PEPA systems. The only components of the system P = 〈V,N,K,F, Comp, P〉 that evolves is the model component P. The other ... Found inside – Page xviDEFINITION OF SYSTEMS BIOLOGY With the detailed introduction given above, we are ready to form our own “informal” definition of systems biology. "A Dictionary of Biology" is an up-to-date reference work explains several thousand specialized words that allow for empirical approaches to the biological sciences. Found inside – Page 18Or rather, it isamixture of two styles: equations are defined for each reagent, but the system definition has the form of a pathway-centric model. Found inside... “wild type” no longer has much meaning. Even more than static aspects, dynamic aspects of biological systems mandate the use of computational models. Found inside – Page 31.2 GENERAL SYSTEMS THEORY General systems theory [11–13] (whose variants ... as a primary concept instrumental for systems definition and description. Advances in computer science and technology and in biology over the last several years have opened up the possibility for computing to help answer fundamental questions in biology and for biology to help with new approaches to computing. Analysis of high-throughput data in the context of a molecular interaction network is particularly informative as it has the potential to reveal the most relevant network modules with respect to a phenotype or biological process of interest ... Found inside – Page 38This is important because when tackling medical problems, from a medical systems biology point of view, we deal in fact with complex systems. Definition 2.1 ... Found inside – Page 7The above may serve to appreciate why there are multiple definitions of systems biology and may provide place for these definitions in perspective. First comprehensive single-authored textbook on genome-scale models and the bottom-up approach to systems biology is was in. 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